Hand-to-hand combat (sometimes abbreviated as HTH or H2H) is a physical confrontation between two or more persons at short range (grappling distance or within the physical reach of a handheld weapon) that does not involve the use of weapons. The phrase "hand-to-hand" sometimes include use of melee weapons such as knives, swords, clubs, spears, axes, or improvised weapons such as entrenching tools. While the term "hand-to-hand combat" originally referred principally to engagements by combatants on the battlefield, it can also refer to any personal physical engagement by two or more people, including law enforcement officers, civilians, and criminals.

Combat within close quarters, to a range just beyond grappling distance, is commonly termed close combat or close-quarters combat. It may include lethal and non-lethal weapons and methods depending upon the restrictions imposed by civilian law, military rules of engagement, or ethical codes. Close combat using firearms or other distance weapons by military combatants at the tactical level is referred to in contemporary parlance as close-quarters battle. The United States Army uses the term combatives to describe various military fighting systems used in hand-to-hand combat training, systems which may incorporate eclectic techniques from several different martial arts and combat sports.